Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control
نویسندگان
چکیده
منابع مشابه
Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control
Misfolded proteins retained in the endoplasmic reticulum (ER) are degraded by the ER-associated degradation pathway. The mechanisms used to sort them from correctly folded proteins remain unclear. Analysis of substrates with defined folded and misfolded domains has revealed a system of sequential checkpoints that recognize topologically distinct domains of polypeptides. The first checkpoint exa...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2004
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.200309132